皮肤弹性测试分析仪

皮肤及组织生物力学特性（柔软度）测量分析仪系统绍

BCT2K组织柔软度测量仪是用来测量一定区域的皮肤或者凝胶组织在一个吸引强制力的作用下的变形以及恢复的能力，其测量样品的种类包括人类及动物皮肤、瘢痕及愈合组织、人工凝胶及植入假体，人工器官、橡胶薄膜、塑胶薄膜等多种材料。 
BCT2K组织柔软度测量仪的测量原理是通过在被测皮肤表面形成负压，使皮肤吸入测试探头，此探头有一对收发光管(激光收发装置)，发光管的激光功率恒定，由于吸入皮肤的深度不同，接收管感应到的激光强度也不同，从而可以得到深度一气压差的曲线，通过分析此曲线就可以得到皮肤的弹性和粘弹性值。

BCT2K系统主要通过一个直径为10mm的探头对测量样品表面施加低压力吸入（0到150 mm Hg），然后被测量区域内的皮肤会被直径为2mm开放式的探头吸入。皮肤或者凝胶进入到探头的深度将会被激光测量系统wu接触测量得到，这个测量是通过一个光学测量系统完成，它是由一个发光器和一个接收器组成的。整个测量过程的加压过程在5秒钟，释放压力过程为15秒钟，整个测量过程通过测量施加压力和释放压力过程中上移形变量zui大值和残值之间的比率，可以分析皮肤或凝胶表面弹性的大小；通过分析其恢复时间和形变量，可以分析皮肤或凝胶柔软度。 
伴随皮肤美容学和临床治疗学的发展，皮肤弹性的wu创性量化评价已经成为研究皮肤表面生物学状况的重要内容。应用BCT2000皮肤及组织柔软度测量仪系统对皮肤弹性进行wu创性检测，结合对影响弹性因素超微结构的组织学及分子机制的研究，将使对各种状态下皮肤弹性的变化有更加quan面、深入的了解。

 

图3 BCT2K的测量过程施加压力和形变关系示意图

图4 BCT2K的测量过程施加压力和形变关系软件界面

图5 BCT2K对皮肤或凝胶的弹性和柔软度的的测量方法

图6 BCT2K对某皮肤样品弹性测量结果示意图
Cited from: Viscoelastic Properties of Human Facial Skin- A Pilot Study. M.W. Beatty · A. Wee · D.B. Marx · L. Ridgway · B. Simetich. Conference Paper. IADR General Session and Exhibition 2014; 06/2014.

案例1：使用BCT2000组织柔软度测量仪对硅胶乳房假体进行柔软度测试 

图7A 待测试的硅胶乳房假体

图7B 使用BCT2K组织柔软度测量仪对其进行柔软度测试

1. 分析其与真实组织的区别，cited from:Silicone gel breast implants: science and testing. Kinney BM1， Jeffers LL， Ratliff GE， Carlisle DA. Plast Reconstr Surg. 2014 Jul;134(1 Suppl):47S-56S.

案例2：使用BCT2K组织柔软度测量仪对烫伤后的瘢痕组织进行弹性测试
分析皮肤在烫伤后愈合的过程中皮肤的弹性、皮肤柔软度及功能方面的恢复程度。

图8A 对烫伤后的瘢痕组织愈合过程

图8B 烫伤后的瘢痕组织不同的恢复时间弹性测试的结果
Cited from: Establishing a Reproducible Hypertrophic Scar following Thermal Injury: A Porcine Model. Scott J. Rapp， MD， Aaron Rumberg， BS， Marty Visscher， PhD， David A. Billmire， MD， Ann S. Schwentker， MD， and Brian S. Pan， MD. Plast Reconstr Surg Glob Open. 2015 Feb; 3(2): e309.

主要应用领域

1. 健康人群皮肤弹性的差异性
2. 皮肤衰老因素调查
3. 病理状态下皮肤的弹性变化
4. 化妆品和激光对皮肤的疗效
5. 皮肤及凝胶类组织的弹性实时测量
6. 皮肤及凝胶类组织的硬度实时测量
7. 体表的创伤愈合和伤口愈合的早期阶段皮肤的弹性特征分析
8. 非破坏性测量完整的人体皮肤，对伤口和弹性材料进行测量

涉及课题案例 
1.烧伤应用湿润培养肉芽后植皮的疗效观察
2.化妆品对皮肤柔软度的影响及评价
3.健康人群皮肤弹性的调查
4.对皮肤病理状态的研究
5.化妆品对皮肤的疗效评价
6.光子嫩肤技术提高皮肤弹性和改善肤质的应用研究
7.异种脱细胞真皮和自体薄皮移植在深度烧伤创面中的临床应用
8.评估人工真皮修复增生性瘢痕的临床疗效
9.人工皮肤用创伤敷料的研究
10.皮肤纹理、粗糙度、弹性与年龄和部位相关性研究
11.应用脂肪组织来源干细胞构建皮肤复合组织的初步研究
12.湿性医疗技术在兔深Ⅱ度烫伤创面愈合的实验研究
13.皮肤保湿剂及保温护理品的配方设计
14.组织工程皮肤的生物学特性及其临床应用评价
15.股前外侧皮瓣游离移植修复小腿及踝部皮肤软组织缺损的临床应用
16.硅胶乳房假体的选择与临床应用
17.化妆品保湿和皮肤弹性间的关系
18.移植合成表型平滑肌细胞改善皮肤弹性的组织工程学研究
19.PLGA静电纺丝纤维膜用于皮肤组织工程
20.miR-23b联合TGFβⅡ型受体拮抗剂治疗皮肤瘢痕的机制研究
21.UVB辐射敏感的致癌miR-365在皮肤鳞癌发生发展中作用机制的研究
22.利用金属蛋白质组学研究砷结合蛋白及其在砷皮肤毒性中的作用
23.肉毒杆菌素与皮肤柔软度和弹性的关系
主要优势 
1.对皮肤弹性测量为wu创型测量，不会对皮肤或材料产生破坏
2.采用高分辨率激光（um）和负压（毫米和毫巴）传感器
4.测量方法简便快捷、技术实现成本较低
5.屏幕进行实时图形更新，可自动计算和自动显示测量结果
6.简单的触摸屏界面，测试流程简单
7.系统为便携式轻量化系统，容易携带，可提供实时数据和结果
8.可选择应力-应变计算，归一化面积和样品厚度
9.应用领域多样，包括对皮肤、软组织和伤口愈合、凝胶材料、薄膜材料等
10.用于输入和分析测试的软件兼容Windows系统，可直接连接打印机进行打印 
11.应用文献多，超过70篇重要文献 
主要参数 
1.样品数据获取速率：10 Hz
2.线性负压增加速率：10mmHg/second
3.系统zui大负压压强：150 mmHg
4.气压传感器分辨率：0.01mmHg
5.真空泵气压范围：1 atm（标准大气压）
6.激光分辨率：3um
7.激光垂直位移范围：0-25 mm
8.电源输入100-240V
9.电源输出24V/2.91A
10.尺寸： 12英寸x10英寸x6英寸（30.48厘米*25.4厘米*15.24厘米）
11.重量：7.7kg

文献：

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• In-Vivo Multiaxial Stress-Strain Analysis of Soft Tissue: An Advancement in the Analysis of Incisional Wound Strength. Vistnes D. M., Perry L. C., G. P. Maxwell, Fisher J. Proceedings from The Biomaterials Society Meeting, Boston, MA. April 1994.
• A New Method for Characterization of Elastic Materials: Compliance Analysis of Silicone Elastomer Shells. Vistnes D., Perry L., Fisher J., Maxwell P., Proceedings from The Biomaterials Society Meeting, Boston, MA. April 1994.
• Characterization of Silicone Elastomer Shells: The Role of Structural Modifications. Vistnes D. M., Perry L. C., Fisher J., Maxwell G. P. Abstracts from the 39th Annual Meeting of the Plastic Surgery Research Council. Ann Arbor, Michigan. June 1994.
• Evaluation of Silicone Gel Sheeting on the Wound Healing of Linear Incisions. Clugston P. A., Vistnes D. M., Perry L. C., Maxwell G. P., Fisher J. Annals of Plast. Surg. 1994, Vol. 34(1) 12-15.
• Materials Characterization System Meets Increasing Demands. Perry, L. Biomaterials forum, Vol 16(4), September 1994.
• The Role of TGF-B1 and EGF in the Wound Healing Process: An In-Vivo Biomechanical Evaluation. Perry LC, Connors AW, Matrisian LM, Nanney LB, Charles D, Reyes D. J Wound Repair and Regen 1993; 1: 41-6.
• A New In-Vivo System for Biomechanical Characterization of Skin and Wound Healing. Perry LC, Fisher J. J 11th Southern Eng Conf 1992:83-4.
• An Improved Method of Wound Disruption and Measurement. Charles D, Williams K III, Perry L C, Fisher J, Rees R. J Surg. Res 1992; 52:214-8.