植物酰基转移酶ELISA试剂盒 英文缩写; AT
植物酰基转移酶ELISA试剂盒 英文缩写; SAD
植物S转移酶ELISA试剂盒 英文缩写; GST
植物羧酸酯酶ELISA试剂盒 英文缩写; CarE
植物花生凝集素ELISA试剂盒 英文缩写; PNA
产品名称:8-dehydro Cholesterol
规格:1mg 5mg 10mg
CAS:70741-38-7
别名:N/A
化学名:cholesta-5,8-dien-3β-ol
分子式:C27H44O
分子量:384.6
溶解度:Soluble in methanol and chloroform
储存条件:Store at -20°C
产品描述:
8-dehydro Cholesterol (8-DHC) is an isomer of the cholesterol precursor 7-DHC .[1][2][3] It accumulates in tissues and plasma in patients with Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in DHCR7, the gene encoding 3β-hydroxysterol-Δ7-reductase, and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. 8-DHC levels are increased in serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 .[1][2][3]
Reference:
[1]. Wolf, C., Chevy, F., Pham, J., et al. Changes in serum sterols of rats treated with 7-dehydrocholesterol-Δ7-reductase inhibitors: Comparison to levels in humans with Smith-Lemli-Opitz syndrome. J. Lipid. Res. 37(6), 1325-1333 (1996).
[2]. Bj?rkhem, I., Starck, L., Andersson, U., et al. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: Abnormal levels of 24S- and 27-hydroxycholesterol. J. Lipid Res. 42(3), 366-371 (2001).
[3]. Griffiths, W.J., Abdel-Khalik, J., Crick, P.J., et al. Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. J. Steroid Biochem. Mol. Biol. 169, 77-87 (2017).
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